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Presenter: Liquin Ren - Microfluidics and Biochip Laboratory, Department of Mechanical and Industrial Engineering, University of Toronto
Supervisor:

Date: Fri, February 14, 2003
Time: 11:00:00 - 00:00:00
Place: EOW 430

ABSTRACT

Abstract:

Biochips or lab-on-a-chip devices have drawn a great deal of attention over the past few years due to the ever-increasing applications in biomedical diagnosis and analysis, such as clinical detection, DNA scanning, and electrophoretic separation. Typically, a biochip is a thin glass plate with a network of microchannels etched into its surface. The target analytes can be transported through these microchannels. The fundamental understanding of the microfluidic transport phenomena in biochips and other lab-on-a-chips is key to the performance of such devices. Therefore, the fundamental studies of the microfluidic transport phenomena in these devices have been carried out both theoretically and experimentally.

This presentation will cover the following topics:

Firstly, a theoretical model of pressure-driven electrokinetic phenomena in microchannels and the experiments specially designed for verifying this model will be presented. The experimental validation of this developed model will be discussed as well.

Then, the electro-osmotic transport phenomena in microchannels will be discussed. The topic will be focused on the electro-osmotic pumping method as a technique for the solution displacement in microchannels. Both the theoretical and experimental results will be presented.

Finally, the transport phenomena in microfluidic dispensers (crossing microchannels) will be discussed to reveal the effects of the electro-osmotic mobility of the buffer solution, the electrophoretic mobility of the sample, the applied electrical field strength and the electrical conductivity gradient of electrolyte solution on the dispensing process.