Eaton, Sarah

Project title: Cancer nanotechnology: Use of gold nanoparticles for improved cancer therapeutics

Department: Physics and Astronomy

Faculty supervisor: Dr. Devika Chithrani

"Gold nanoparticles are being used as radiation dose enhancers in cancer therapy. I will be using gold nanoparticles encapsulated in liposomes as my therapeutic system for this study.  Breast cancer cells (MDA-MB-231) will be first incubated with the nanoparticle system. Once nanoparticles are internalized within cells, a radiation dose of 2 Gy will be given. Effectiveness of the treatment will be assessed using clonogenic assay. As an NSERC USRA student, I am studying the cellular uptake of this nanoparticle system. If I am given this award, I have the opportunity to test this nanoparticle system in radiation therapy."