Event Details
Optimized Numerical Mapping Scheme for Filter-Based Exon Location in DNA Using a Quasi-Newton Algorithm
Presenter: Parameswaran Ramachandran
Supervisor:
Date: Tue, May 25, 2010
Time: 13:00:00 - 14:00:00
Place: EOW 430
ABSTRACT
ABSTRACT
An optimized numerical mapping scheme for achieving improved location of exons in DNA sequences using digital filters is proposed. Characteristic numerical values for the four nucleotides, referred to as pseudo-EIIP values, are obtained using a training procedure where the location accuracy is maximized using a quasi-Newton algorithm based on the Broyden-Fletcher-Goldfarb-Shanno updating formula. The objective function for the optimization procedure is formulated using the so-called receiver operating characteristic (ROC) technique and the procedure is initialized using electron-ion interaction potential (EIIP) values. Simulation results show that the pseudo-EIIP values yield more accurate exon locations than those obtained using the actual EIIP values.