Dr. William Hintz

Dr. William Hintz
Office: PCH 009

Areas of research focus

  • Fungal genetics
  • Plant and animal pathogens
  • Biological control
  • Population genetics
  • Dutch elm disease

We are primarily interested in host pathogen interactions between fungi and a variety of plant and animal pathos systems. Our model organism is the fungus Ophiostoma novo-ulmi, the causal agent of Dutch Elm disease which was introduced to Canada during the last century. We are tracking the spread of this organism as it marches relentlessly across the country, assessing the population structure by genomic analysis, and examining at the molecular level the communication between host and pathogen.

What we have learned from this model system we are applying to other pathogens such as Sydowia sp. affecting seed production in tree species targeted for reforestation and Saprolegnia parasitica, and other newly described fungal and bacterial pathogens, impacting finfish aquaculture. Through the application of genomics approaches we strive to understand the origins of pathogens and predict potential outbreaks such that we can develop mitigation strategies.

  • Biol 401A Biotechnology
  • Biol 415C Mycology

de la Bastide, PY, J LeBlanc, L Kong, T Finston, EM May, R Reich, WE Hintz, and P. von Aderkas. 2018. Fungal colonizers and seed loss in lodgepole pine orchards of British Columbia. Botany (Accepted for publication).

de la Bastide, PY, C Naumann, and WE Hintz. 2018. Assessment of the intraspecific variability of Saprolegnia parasitica populations in aquaculture facilities of British Columbia. Diseases of Aquatic Organisms 128: 235-248.

O'Hanlon SJ, Rieux A, Farrer RA, Rosa GM, Waldman B, Bataille A, Kosch TA, Murray KA, Brankovics B, Fumagalli M, Martin MD, Wales N, Alvarado-Rybak M, Bates KA, Berger L, Böll S, Brookes L, Clare F, Courtois EA, Cunningham AA, Doherty-Bone TM, Ghosh P, Gower DJ, Hintz WE, Höglund J, Jenkinson TS, Lin CF, Laurila A, Loyau A, Martel A, Meurling S, Miaud C, Minting P, Pasmans F, Schmeller DS, Schmidt BR, Shelton JMG, Skerratt LF, Smith F, Soto-Azat C, Spagnoletti M, Tessa G, Toledo LF, Valenzuela-Sánchez A, Verster R, Vörös J, Webb RJ, Wierzbicki C, Wombwell E, Zamudio KR, Aanensen DM, James TY, Gilbert MTP, Weldon C, Bosch J, Balloux F, Garner TWJ, and Fisher MC. 2018. Recent Asian origin of chytrid fungi causing global amphibian declines. Science 360(6389): 621-627.

Hamberg, L, PY de la Bastide, W Hintz, SF Shamoun, M Brandtberg, and J Hantula. 2018. Interfertility and genetic variability among European and North American isolates of the basidiomycete fungus Chondrostereum purpureum. Fungal Biology 122: 659-667.

de la Bastide, PY, WL Leung, C Naumann, and WE Hintz. 2016. Species composition and diversity of the genus Saprolegnia in fin fish aquaculture systems.  Bulletin of the Aquaculture Association of Canada 2: 6-12.

de la Bastide, PY, WL Leung, and WE Hintz. 2015. Species composition of the genus Saprolegnia in fin fish aquaculture environments, as determined by nucleotide sequence analysis of the nuclear rDNA ITS regions. Fungal Biology 119: 27-43.

LeBlanc, J, Faruk, A, Dort, E, Govindarajulu, P, Quah, E, Muin, MA, and Hintz, W 2014. A multi-year surveillance for the pathogen Batrachochytrium dendrobatidis (Bd) potentially infecting amphibians of Peninsular Malaysia.  Herp. Rev. 45(4):603-608.

Hintz, WE, Carneiro, JS, Kassatenko, I, Varga, A, and James, D. 2013. Two novel mitoviruses from a Canadian isolate of the Dutch elm pathogen Ophiostoma novo-ulmi (93-1224). Virology Journal 10:252-264.

Carneiro, J, PY de la Bastide and WE Hintz. 2013. Regulated gene silencing in the fungal pathogen Ophiostoma novo-ulmi. Physiological and Molecular Plant Pathology 82:28-34.

Forgetta, V, Levesque, G, Dias, J, Grove, D, Lyons Jr, R, Genik, S, Wright, C, Singh, S, Peterson, N, Zianni, M, Kieleczawa, J, Hintz, W, Jacobi, V, Bernier, L Levesque, R, and Dewar, K. 2012. Comparison of multiple genome sequencing centers and analysis of the Dutch elm disease fungus genome using the Roche/454 GS-FLX Titanium System. Journal of Biomolecular Techniques 24:39-49.