Ebert, Sarah

Project title: Pannexin 1 in cortical neuron plasticity

Department: Medical Sciences

Faculty supervisor: Dr. Leigh Anne Swayne

"The project builds on our lab’s previous work demonstrating the channel protein Pannexin 1 regulates network properties and synapse formation in cortical neurons. The focus of the JCURA project will be to further investigate synaptic physiology in primary cortical neurons from the Pannexin 1 KO mouse. In order to address this, I will compare spontaneous potentials from cultured cortical neuron cells using perforated patch clamped electrophysiology in primary cultures of wildtype and Panx1 KO cortical neurons. This information will further our understanding of the functional role of Pannexin 1 at synapses."