Biophysical and biochemical studies of DNA-protein interactions involved in chromatin assembly and gene expression.
Protein-carbohydrate recognition using molecular biological, biochemical, biophysical, and structural methods.
Application of mass spectrometry, proteomics, photoaffinity labelling, and molecular modelling to determine protein structure.
Structural and biophysical basis of host-parasite pathogenicity, small molecule therapeutics, and novel structure of enzymes in bioremediation.
Biochemistry and cell biology of signaling in early animal development.
Bioinformatic, genomic and proteomic approaches to pathogenesis of spirochetes.
Structural biology of protein-carbohydrate recognition; x-ray crystallography and scientific visualisation.
The effect of environmental pollutants on hormonal signalling in development and disease.
Biogenesis and function of miRNAs in stem cells, EphA2 and EphrinA1 in cancer, and rewiring of tyrosine pathway in cancer.
Cellular metabolism in cell death and survival, control of T cell function by autophagy and immunotherapy approaches to target cancer stem cells; Scientist, Trev & Joyce Deeley Research Centre, BC Cancer Agency.
Function of pathogenicity proteins of Franciscella, synthetic biology using cold-loving bacteria, and development of expression systems for cyanobacteria.
Immune response to cancer, immunotherapy, T cell biology, cytokines, signal transduction and cell cycle regulation. Director of the Trev and Joyce Deeley Research Centre, BC Cancer Agency.
Regulation of gene expression by novel chromatin modifying enzymes in yeast and mammalian cells.
Pathogenesis of trypanosomes parasites using antibody-based technologies, and antibody enrichment techniques for quantitative mass spectrometry.
Nucleic acid-protein interactions in the regulation of gene expression, structure and function of oncogenes, tumour suppressors, and bacterial virulence factors.
Viral bioinformatics and computer technologies to analyze viral genomes.
Dr. N. Leigh Anderson, BA, PhD (Cambridge), Adjunct Professor
Visit Dr. Anderson's web page
Research interests: Plasma Proteome
Human plasma proteomics and biomarkers of disease and quantitative mass spectrometry.
Application of mass spectrometry and other analytical techniques to proteomics, metabolomics, metal biogeochemistry and environmental research.
Neurogenesis and the bioelectric control of new neurons in healthy and injured/diseased brain. Evaluation of specific ion channels as therapeutic targets for brain repair.
Molecular genetics of breast cancer. Director of the Tumour Tissue Repository at the Deeley Cancer Research Centre, BC Cancer Agency.
Cellular immunity and immune responses to peptide eptitopes, and vaccine development for cervical cancer.
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