Biochemistry & Microbiology
Interested in the molecular basis of life?
Our undergraduate programs combine biochemistry and microbiology - the two disciplines central to molecular biology and biotechnology. We offer courses that emphasize modern laboratory techniques taught by award winning teachers. Our honours programs offer you the opportunity to study with world renowned researchers.
New to biochemistry?
Check out BIOC 102 Biochemistry & Human Health
Here is our preliminary summer timetable:
Michael Przybylski, Laboratory of Analytical Chemistry and Biopolymer Structure Analysis, University of Konstanz
Michael Przybylski studied chemistry and completed his PhD dissertation at the University of Mainz. After being research associate in Bioorganic Chemistry at Mainz, he spent two years as a Visiting Scientist at the National Cancer Institute, NIH/USA. He was Associate Professor in Organic and Biopolymer Chemistry at the University of Mainz, and was appointed in 1989 to the Professorship and Head of Analytical Chemistry at the University of Konstanz, where he is the Director of the Laboratory of Analytical Chemistry and Biopolymer Structure Analysis. Since then his laboratory has made numerous developments and applications of biopolymer mass spectrometry methods, combined with protein- and peptide-chemical methods, tertiary structure analysis by protein-chemical modification and mass spectrometry, and mass spectrometric determination of biopolymer recognition structures. His laboratory has invented proteolytic-excision mass spectrometry for the elucidation of protein-ligand interaction structures, and peptide/protein epitopes, and has elucidated the structure of several membrane proteins, such as Lung Surfactant protein-C.
The laboratory’s current research is focused on applications of mass spectrometry and peptide biochemistry to structure and mechanism of neurodegenerative proteins; pathophysiological protein modification; vaccine chemistry; structure and epitope analysis of therapeutic antibodies; affinity-mass spectrometry of biopolymer interaction epitopes; mass spectrometric elucidation of oligomerisation/truncation pathways and structures of “misfolding”/aggregating proteins in neurodegenerative diseases.
Michael Przybylski has been awarded the St Denis Prize in Cancer Research; several international Guest Professorships; the Life Science Prize of the German Society for Mass Spectrometry; an honorary doctoral degree of the University of Iasi, RO; He is currently Guest Professor of the Chinese Academy of Sciences, Changchun, and of Jilin University, China. He has been member of Scientific Committees of several International Conferences, has been Editor and is Editorial Board member of several International Journals in the field of biopolymer chemistry and mass spectrometry, and has been Chairman of the German Society for Mass Spectrometry. He has been coordinator of two previous FP5 and FP6 EU projects. He has served as scientific advisor, and board member of several international Research Institutions in mass spectrometry and proteomics, and is member of the Graduate School “Chemical Biology”, and board member of the “Zukunftskolleg”, two recently appointed Excellence Centers of the University of Konstanz. He has ca. 300 publications in International Journals; 6 monographs/reviews; ca. 25 patents; ca. 100 invited lectures.
Congratulations to our Honours (Biochemistry) student Dylan Collins, who has been awarded the very prestigious Rhodes Scholarship. Dylan will be attending Oxford University commencing Fall 2014. Below is an excerpt from Dylan’s Rhodes Scholarship webpage.
"Dylan is currently reading for a Bachelor of Science degree in Biochemistry and is passionate about improving health equity and harm reduction. Last year he partook in the Complex Humanitarian Emergency Leadership Training Program at the University of California, San Francisco. He is a current board member of AIDS Vancouver Island and has worked with the BC Centre for Disease Control, the Foundation for Sustainable Development, and KPMG’s management consulting practice. For relaxation Dylan enjoys cycling, sailing, Bhangra and is excited about rowing. In the long term, Dylan aspires to be able to inform and influence public policy regarding health especially along the lines of harm reduction."
Scholarships and Awards
Susannah Gagnon: NSERC CGS-M
Geoff Gudavicius: Alexander Graham Bell CGS-D (ongoing)
Vikes announce major award winners at annual banquet.
Kyle Irvine is a BIOC/MICR co-op student who has completed 6 co-op work terms plus won many medals as a runner. He will be graduating in June 2014.
Ross Prager (microbiology honours) is the Co-op Student of the Year for the Optional and Professional Co-op Programs. We asked Ross what attracted him to the co-op program and to describe his co-op experience.
"I first became interested in the Biochemistry and Microbiology (BCMB) co-op program with the hope that through science related work experience I could narrow down possible career options. Having now completed 3 co-op terms: a volunteer work term with St. John Ambulance Victoria, a work term in Dr. Leigh Anne Swayne's cellular and molecular neuroscience lab, and a work term as a paramedic with the British Columbia Ambulance Service, I know that co-op has truly enriched my undergraduate experience, and has allowed me to explore several different career options. Throughout this process, the BCMB co-op coordinator Dr. Rozanne Poulson has been incredibly supportive and integral to my positive co-op experience. She has helped me apply for jobs, funding, and develop my resume. I wholeheartedly recommend that anyone completing a Biochemistry or Microbiology undergraduate degree should consider co-op, as I am sure it will be as positive an experience for them, as it has been for me."
Amanda Carew from Dr. Caren Helbing’s lab has received the Dr. Richard Playle Award for Outstanding MSc Thesis in Aquatic Toxicology, for her work on "The sublethal effects of nanosilver on thyroid hormone-dependent frog metamorphosis". This award is given by the Aquatic Toxicity Workshop, a national organization of toxicologists.
Congratulations to Andrew Leung, recipient of the BCMB Graduate Teaching Assistant Award 2013. Andrew is picture here receiving the award from the Chair, Dr. Robert Burke. This award is given annually to a graduate student TA who demonstrates an outstanding ability to work with the undergraduates in the teaching labs. Andrew is approachable, knowledgeable, and well prepared for his teaching assistant duties.
Michelle attended the 12th International Congress on Toxoplasmosis in Oxford, England at the end of June 2013. For her poster and short talk entitled "Toxoplasma gondii sporozoites invade host cells using two novel paralogues of RON2 and AMA1", which represented work from a collaboration between our lab, Heather Fritz at UC Davis and John Boothroyd's lab at Stanford, she won the "Elsevier Investigator Award - Best Short Talk/Poster".
Jennifer Evancio (left) received first prize at the 2013 Honours Fest. She is an Honours student in Dr. Marty Boulanger's lab. Jennifer's poster was entitled "Purification and Crystallization of Trypanosoma brucei BARP". Her research focused on Brucei alanine-rich protein (BARP), a Trypanosoma brucei surface protein present when the parasite is in the epimastigote stage in the tsetse fly. The goal of this project was to recombinantly express, purify, and crystallize the protein for structural characterization by xray crystallography.
Rob Mackenzie (left) received honorable mention at the 2013 Honours Fest. Rob, a Biochemistry and Microbiology Honours student, carried out his research in Dr. Brian Christie's lab in the Division of Medical Science. His poster is entitled: "Alterations of the N-methyl-D-aspartate receptor subunit profile in the developing rat hippocampus following mild traumatic brain injury". Rob's research focused on the N-methyl-D-aspartate (NMDA) receptor, a heterotetrameric, ligand-gated cation channel that is involved in synaptic plasticity. The purpose of this study was to characterize possible alterations of NMDA receptor subunits in a rodent model for juvenile concussion using a semi-quantitative, densitometric analysis of protein immunoblots.
Jenna Ries has been awawded the 2012 ACE (Association for Co-operative Education in BC) Co-op Student of the Year. In their letter to Jenna, they state:
"This award recognizes a BC or Yukon Co-op student who demonstrates an outstanding level of achievement in their Co-op position and in their academic studies, and also makes significant contributions to co-operative education and in their volunteer activities at school and in the community.
The Awards Committee was extremely impressed with all of your achievements during your work term with the BC Cancer Agency’s Deeley Research Centre; your strong academic record through your Bachelor of Science degree program; your publishing and research accomplishments; as well as your dedication to supporting your peers through mentoring and student leadership activities at the University of Victoria."
Jenna Ries (biochemistry) is the 2012 Co-op Student of the Year for Optional and Professional Programs. She has completed work terms with the National Research Council of Canada and the BC Cancer Agency Deeley Research Centre, where she co-authored two papers in the peer-reviewed scientific journals Autophagy (Landes Bioscience) and The Journal of Pathology (Wiley Publishing). "Jenna's work made it possible for us to publish our findings in a short period of time, which undoubtedly helped to raise the profile of our research both regionally and internationally," says supervisor Dr. Julian J. Lum of the BC Cancer Agency. "I would rank her performance, productivity and contribution in the top 5% of all students at her career stage."
Congratulations to David Dilworth, recipient of the BCMB Graduate Teaching Award 2012. David was presented with the award by Dr. Robert Burke, Chair of the department.
The Microbiology 200 lab instructors have this to say of David:
"Dave was an exceptional TA. He consistently went above and beyond in terms of preparation for the lab and assistance to the Instructor and students during the lab. Dave was very personable and professional and received many positive comments from students on their course evaluations."
In BCMB 406, Dave was instrumental in the development of the new ChIP lab. He worked well independently processing the qPCR samples. He was an efficient marker and gave the students extensive feedback on their assignments.
Michelle has been accepted to the EMBO Practical Course on Structural Characterization of Macromolecular Complexes being held in Grenoble, France June 4-9, 2012. She is one of 20 successful candidates chosen from a field of 179 applicants consisting of PhD students, Post-docs, MSc students, undergrads and other scientists from around the world.
Michelle has provided this description of her research project: “There are more than five thousand species of Apicomplexan parasites, including Plasmodium and Toxoplasma (the etiological agents of malaria and toxoplasmosis, respectively), that together cause globally devastating diseases leading to millions of deaths every year. My research project is focused on elucidating the conserved mechanism used by these diverse parasites to invade host cells. A detailed understanding of the essential steps in invasion will provide a solid foundation for the engineering of broadly neutralizing therapeutics targeting the Apicomplexans.
Michael McClean has been named 2012 Biochemistry & Microbiology Co-op Student of the Year. Mike has excelled in the classroom and on his Co-op placements. Dr. Francis Choy, Mike's most recent Co-op supervisor, noted "Mike exemplifies what a model co-op student in molecular biology research at UVic is about and raises the bar to a new high standard."
Mike provided the following account of his Co-op experience at the BIOC/MICR Co-op student recruiting event last year:
"I joined Co-op as a second-year student solely to enhance my medical school applications. Unbeknown to me at the time, that decision resulted in a profound and positive change in my outlook. After two work terms, I had become passionate about my studies and developed a new view of the whole UVic experience. Co-op provided me with role models and friends who have helped me out during tough times and who I know I can rely on today and tomorrow for support and advice. I gained much knowledge and many skills during my work terms but, most importantly, I gained the confidence to question and critique what I hear and read. Although many Co-op programs are optional, in my experience Co-op is a mandantory part of a successful degree at UVic. There is no downside to cooperative education. Even if you don't get the most prestigious placements, in the end you will have grown in ways you never expected and never would achieve by only attending classes."
Lyndsay Spriggs graduated from UVic with a BSc Honours in 2009. She studied with Dr. Francis Choy in Biology and continued to complete her Honours degree in the Department of Biochemistry and Microbiology in Dr. Juan Ausio's lab. She published her research, as first author in the Journal of Medicinal Chemistry:
Sprigg, L., Li, A., Choy, F.Y.M., and Ausio, J. 2010. Interaction of daunomycin with acetylated chromatin. Journal of Medicinal Chemistry 53 (17), 6457-6465.
Lyndsay was awarded the International North Rhine-Westphalia (NRW) research award for her work.
Dr. Choy writes this of Lyndsay:
"Upon graduation in June 2009 with an Hons. B.Sc. in Biochemistry and Microbiology at UVic, Lyndsay continued her research with the B.C. Cancer Agency in Vancouver for a year. She applied for admission to study Medicine at UBC to further advance her study in the field. Because of Lyndsay's academic and research excellence, she was admitted by UBC Faculty of Medicine in August 2011 and is currently studying Medicine at the UBC Kelowna campus. Regarding the award, the NRW Research Schools were founded as an initiative of the German federal State of North Rhine-Westphalia (NRW). International networks of renowned scientists, world leading supervisors and excellent scientific environments – the NRW Research Schools provide a forum for pre-doctoral candidates with superior academic track records. In the summer of 2011, they sent the Dean of Science at UVic a flyer inviting UVic faculties to nominate outstanding undergraduate research students for this award. I communicated with Juan and we subsequently nominated Lyndsay for this award under the category Cell Dynamics and Disease (Biomedicine, Molecules and Cells). In November,we were informed that Lyndsay received the highest ratings from the adjudicating committee in this category and was given the top award."
Congratulations to Brett Eyford, recipient of the BCMB Graduate Teaching Award 2011. Brett was presented with the award by Dr. Robert Burke, Chair of the department.
Dr. Caren Helbing and Dr. Inanc Birol (Michael Smith Genome Sciences Centre) have been funded by Genome BC's Strategic Opportunities Fund (SOF) program for their project: A leap in technology: Frog reference genome assembly and annotation. Amphibians are sentinel species of environmental health. The research goals of this project are to identify the genome and transcriptome of the bullfrog. This could subsequently be used to develop genomic tools to assist in early detection of changes in sensitive habitats. For details, please see the announcement on the Genome BC website. (photo courtesy of Dennis Churchill)
Dr. Robert Burke, Chair of the Department, says this of Marty: "The Research Excellence Award is recognition that normal standards have been surpassed by research of exceptional merit. I believe that there are several clear indications that Marty has accomplished this. The quality of his publications, the grants and awards he has received, the recognition of his peers and the leaders in the field all indicate that Marty’s research is worthy of this important distinction. Marty is the epitome of what this award intends to recognize – a young scientist who is doing world-class research."
Apicomplexan parasites such as Toxoplasma. gondii (toxoplasmosis) and Plasmodium spp. (malaria) pose a major risk to human health on a global scale. To survive host immunity, those pathogens take refuge inside the protective environment of host cells. Thus, understanding the mechanisms that govern host cell attachment and invasion is central to defining parasite virulence characteristics and to controlling their pathogenesis, and is a major research focus in the Boulanger lab.
Dr. Al Boraston (pictured here with Governor General David Johnston) was one of six outstanding Canadian University faculty researchers awarded a prestigious 2012 E.W.R. Steacie Memorial Fellowship.
For the next two years Dr. Boraston will be able to devote his time and resources to his research on carbohydrate-binding proteins, and their potential application in fighting microbial infections and generation of biofuels.
Photo credit: MCpl Dany Veillette, Rideau Hall © 2012 Office of the Secretary to the Governor General of Canada
Pesticides, drugs and industrial effluents are being released into the environment daily, yet we know little about their adverse effects. Biochemist Caren Helbing is working hard to change that.
Over the past decade, Dr. Helbing has provided advanced scientific tools and technical training to regulatory agencies and private sector companies to help them generate meaningful environmental assessment information. She continues to develop new technology for environmental monitoring.